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Single-cell RNA sequencing studies in murine smoke models have identified an excessive influx of monocyte-derived macrophage subset population responsible for heightened inflammation and ECM remodeling, a finding that has also been validated in emphysematous COPD patients 59

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very low concentration in plasma, and the additional problem that the effect of the substances in the liver can last for a long time, even if the active substance itself is no longer detectable in plasma, the direct detection of coumarin derivatives is generally of little help in clinical cases

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